Sahib Khalsa - Faculty & Adjuncts

Sahib Khalsa, MD, PhD

Sahib Khalsa, MD, PhD
Associate Professor of Community Medicine
College of Health Sciences
Community Medicine
918-502-5743 Website Laureate Institute for Brain Research

Education

PhD – University of Iowa M.D. – University of Iowa Carver College of Medicine Residency in Psychiatry – University of California, Los Angeles, Semel Institute for Neuroscience and Human Behavior BS – State University of New York at Stony Brook

Bio

Dr. Khalsa received a B.S. in Psychology from SUNY Stony Brook in 2002. He graduated from the Medical Scientist Training Program at the University of Iowa, receiving M.D. and Ph.D. (neuroscience) degrees in 2009. He completed his residency training in Psychiatry at UCLA in 2013, serving as the program Chief Resident and Chief Resident in the UCLA Anxiety Disorders Clinic. At that time, he joined the department as a faculty member in the Division of Adult Psychiatry at UCLA, becoming an Assistant Professor in Residence in 2014. Dr. Khalsa’s research examines how people feel their heartbeat, how the human brain maps cardiac sensation, and whether there is dysfunctional cross talk between the heart and brain in psychiatric and cardiovascular illnesses. To approach these questions, his studies have examined the effects of aging, focal brain injury, cardiac dysfunction, and long-term meditation practice on awareness of the heartbeat. Ongoing projects examine the neural basis of cardiac sensation, the neural basis of dysfunctional heart-brain communication in anorexia nervosa, and the impact of implantable cardioverter defibrillators (ICD) on awareness of the heartbeat. These studies aim to ultimately answer the question “How can we develop new treatments that re-establish a functional dialogue between the heart and brain?” Dr. Khalsa’s clinical expertise focuses on the assessment and treatment of anxiety disorders. As a faculty member Dr. Khalsa served as Associate Director of the UCLA Anxiety Disorders Clinic, supervising resident physicians in the treatment of anxiety disorders. As founding Director of the Healthy Hearts Behavioral Medicine Program, an interdisciplinary endeavor started with the UCLA Cardiac Arrhythmia Center, he specializes in treating anxiety and mood disorders in individuals with cardiovascular disease and who have received ICDs. He also worked as an attending psychiatrist in the UCLA OCD Intensive Outpatient Program. In February 2015, Dr. Khalsa joined the Laureate Institute for Brain Research in Tulsa, Oklahoma, as the Director of Clinical Studies, and as an Assistant Professor (tenure track) on the Faculty of Community Medicine at the University of Tulsa.

Publications

Journal Articles

  • Paulus M., Feinstein J., and Khalsa S. An Active Inference Approach to Interoceptive Psychopathology. Vol. 15, Annual review of clinical psychology, 2019, pp. 97-122.
  • Khalsa S. Interoception in Eating Disorders: A Clinical Primer. Psychiatric Times, 2019.
  • Al Zoubi O., Mayeli A., Tsuchiyagaito A., Misaki M., Zotev V., Refai H., Paulus M., and Bodurka J. EEG Microstates Temporal Dynamics Differentiate Individuals With Mood and Anxiety Disorders From Healthy Subjects. Vol. 13, Frontiers in human neuroscience, 2019, p. 56.
  • Maier A., Scheele D., Spengler F., Menba T., Mohr F., Güntürkün O., Stoffel-Wagner B., Kinfe T., Maier W., Khalsa S., and Hurlemann R. Oxytocin Reduces a Chemosensory-Induced Stress Bias in Social Perception. Vol. 44, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019, pp. 281-8.
  • Khalsa S., Adolphs R., Cameron O., Critchley H., Davenport P., Feinstein J., Feusner J., Garfinkel S., Lane R., Mehling W., Meuret A., Nemeroff C., Oppenheimer S., Petzschner F., Pollatos O., Rhudy J., Schramm L., Simmons W., Stein M., Stephan K., Van den Bergh O., Van Diest I., von Leupoldt A., and Paulus M. Interoception and Mental Health: A Roadmap. Vol. 3, Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018, pp. 501-13.
  • Interoception and Mental Health: A Roadmap. Vol. 3, Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018, pp. 501-13.
  • DeVille D., Kerr K., Avery J., Burrows K., Bodurka J., Feinstein J., Khalsa S., Paulus M., and Simmons W. The Neural Bases of Interoceptive Encoding and Recall in Healthy Adults and Adults With Depression. Vol. 3, Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018, pp. 546-54.
  • Hassanpour M., Luo Q., Simmons W., Feinstein J., Paulus M., Luh W., Bodurka J., and Khalsa S. Cardiorespiratory Noise Correction Improves the ASL Signal. Vol. 39, Human brain mapping, 2018, pp. 2353-67.
  • Khalsa S., Feinstein J., Simmons W., and Paulus M. Taking Aim at Interoception’s Role in Mental Health. Vol. 3, Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018, pp. 496-8.
  • Feinstein J., Khalsa S., Yeh H., Al Zoubi O., Arevian A., Wohlrab C., Pantino M., Cartmell L., Simmons W., Stein M., and Paulus M. The Elicitation of Relaxation and Interoceptive Awareness Using Floatation Therapy in Individuals With High Anxiety Sensitivity. Vol. 3, Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018, pp. 555-62.
  • Feinstein J., Khalsa S., Yeh H., Wohlrab C., Simmons W., Stein M., and Paulus M. Examining the Short-Term Anxiolytic and Antidepressant Effect of Floatation-REST. Vol. 13, PloS one, 2018, p. e0190292.
  • Hassanpour M., Simmons W., Feinstein J., Luo Q., Lapidus R., Bodurka J., Paulus M., and Khalsa S. The Insular Cortex Dynamically Maps Changes in Cardiorespiratory Interoception. Vol. 43, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, pp. 426-34.
  • Le T., Kuplicki R., McKinney B., Yeh H., Thompson W., and Paulus M. A Nonlinear Simulation Framework Supports Adjusting for Age When Analyzing BrainAGE. Vol. 10, Frontiers in aging neuroscience, 2018, p. 317.
  • Khalsa S., Hassanpour M., Strober M., Craske M., Arevian A., and Feusner J. Interoceptive Anxiety and Body Representation in Anorexia Nervosa. Vol. 9, Frontiers in psychiatry, 2018, p. 444.
  • Rangaprakash D., Bohon C., Lawrence K., Moody T., Morfini F., Khalsa S., Strober M., and Feusner J. Aberrant Dynamic Connectivity for Fear Processing in Anorexia Nervosa and Body Dysmorphic Disorder. Vol. 9, Frontiers in psychiatry, 2018, p. 273.
  • Khalsa, Sahib et al. “What Happens after Treatment? A Systematic Review of Relapse, Remission, and Recovery in Anorexia Nervosa.” Journal of eating disorders 5 (2017): 20. Print.

  • Smith, R et al. “The Hierarchical Basis of Neurovisceral Integration.” Neuroscience and biobehavioral reviews 75 (2017): 274–296. Print.

  • Hassanpour M., Yan L., Wang D., Lapidus R., Arevian A., Simmons W., Feusner J., and Khalsa S. How the Heart Speaks to the Brain: Neural Activity During Cardiorespiratory Interoceptive Stimulation. Vol. 371, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016.
  • Khalsa S., and Lapidus R. Can Interoception Improve the Pragmatic Search for Biomarkers in Psychiatry?. Vol. 7, Frontiers in psychiatry, 2016, p. 121.
  • Feinstein J., Khalsa S., Salomons T., Prkachin K., Frey-Law L., Lee J., Tranel D., and Rudrauf D. Preserved Emotional Awareness of Pain in a Patient With Extensive Bilateral Damage to the Insula, Anterior Cingulate, and Amygdala. Vol. 221, Brain structure & function, 2016, pp. 1499-511.
  • Khalsa S., Feinstein J., Li W., Feusner J., Adolphs R., and Hurlemann R. Panic Anxiety in Humans With Bilateral Amygdala Lesions: Pharmacological Induction via Cardiorespiratory Interoceptive Pathways. Vol. 36, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, pp. 3559-66.
  • Avery, Jason et al. “How the Brain Wants What the Body Needs: The Neural Basis of Positive Alliesthesia.” Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2016): n. pag. Print.

  • Khalsa, Sahib, and R Lapidus. “Can Interoception Improve the Pragmatic Search for Biomarkers in Psychiatry?” Frontiers in Psychiatry (2016): n. pag. Print.

  • Khalsa, Sahib et al. “Mammillary Body Volume Abnormalities in Anorexia Nervosa.” International Journal of Eating Disorders (2016): n. pag. Print.

  • Zhang, A et al. “Brain Connectome Modularity in Weight-Restored Anorexia Nervosa and Body Dysmorphic Disorder.” Psychological medicine (2016): 1–13. Print.

  • How the Brain Wants What the Body Needs: The Neural Basis of Positive Alliesthesia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016.
  • Shivkumar, K et al. “Clinical Neurocardiology Defining the Value of Neuroscience-Based Cardiovascular Therapeutics.” The Journal of physiology 594.14 (2016): 3911–54. Print.

  • Khalsa S., Kumar R., Patel V., Strober M., and Feusner J. Mammillary Body Volume Abnormalities in Anorexia Nervosa. The International journal of eating disorders, 2016.
  • Preserved Emotional Awareness of Pain in a Patient With Extensive Bilateral Damage to the Insula, Anterior Cingulate, and Amygdala. Vol. 221, Brain structure & function, 2016, pp. 1499-511.
  • Panic Anxiety in Humans With Bilateral Amygdala Lesions: Pharmacological Induction via Cardiorespiratory Interoceptive Pathways. Vol. 36, The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, pp. 3559-66.
  • Khalsa S., Craske M., Li W., Vangala S., Strober M., and Feusner J. Altered Interoceptive Awareness in Anorexia Nervosa: Effects of Meal Anticipation, Consumption and Bodily Arousal. Vol. 48, The International journal of eating disorders, 2015, pp. 889-97.
  • Li W., Lai T., Loo S., Strober M., Mohammad-Rezazadeh I., Khalsa S., and Feusner J. Aberrant Early Visual Neural Activity and Brain-Behavior Relationships in Anorexia Nervosa and Body Dysmorphic Disorder. Vol. 9, Frontiers in human neuroscience, 2015, p. 301.
  • Feusner J., Moody T., Lai T., Sheen C., Khalsa S., Brown J., Levitt J., Alger J., and O’Neill J. Brain Connectivity and Prediction of Relapse After Cognitive-Behavioral Therapy in Obsessive-Compulsive Disorder. Vol. 6, Frontiers in psychiatry, 2015, p. 74.
  • Khalsa S., Rudrauf D., Davidson R., and Tranel D. The Effect of Meditation on Regulation of Internal Body States. Vol. 6, Frontiers in psychology, 2015, p. 924.
  • Khalsa S., Shahabi L., Ajijola O., Bystritsky A., Naliboff B., and Shivkumar K. Synergistic Application of Cardiac Sympathetic Decentralization and Comprehensive Psychiatric Treatment in the Management of Anxiety and Electrical Storm. Vol. 7, Frontiers in integrative neuroscience, 2014, p. 98.
  • Bystritsky A., Khalsa S., Cameron M., and Schiffman J. Current Diagnosis and Treatment of Anxiety Disorders. Vol. 38, P & T : a peer-reviewed journal for formulary management, 2013, pp. 30-57.
  • Philippi C., Feinstein J., Khalsa S., Damasio A., Tranel D., Landini G., Williford K., and Rudrauf D. Preserved Self-Awareness Following Extensive Bilateral Brain Damage to the Insula, Anterior Cingulate, and Medial Prefrontal Cortices. Vol. 7, PloS one, 2012, p. e38413.
  • Preserved Self-Awareness Following Extensive Bilateral Brain Damage to the Insula, Anterior Cingulate, and Medial Prefrontal Cortices. Vol. 7, PloS one, 2012, p. e38413.
  • Khalsa S., J S., and A B. Treatment-Resistant OCD: Options Beyond First Line Medications. Vol. 10, Current Psychiatry, 2011, pp. 45-52.
  • Feinstein J., Rudrauf D., Khalsa S., Cassell M., Bruss J., Grabowski T., and Tranel D. Bilateral Limbic System Destruction in Man. Vol. 32, Journal of clinical and experimental neuropsychology, 2010, pp. 88-106.
  • Bilateral Limbic System Destruction in Man. Vol. 32, Journal of clinical and experimental neuropsychology, 2010, pp. 88-106.
  • Khalsa S., Rudrauf D., Feinstein J., and Tranel D. The Pathways of Interoceptive Awareness. Vol. 12, Nature neuroscience, 2009, pp. 1494-6.
  • The Pathways of Interoceptive Awareness. Vol. 12, Nature neuroscience, 2009, pp. 1494-6.
  • Khalsa S., Rudrauf D., and Tranel D. Interoceptive Awareness Declines With Age. Vol. 46, Psychophysiology, 2009, pp. 1130-6.
  • Khalsa S., Rudrauf D., Sandesara C., Olshansky B., and Tranel D. Bolus Isoproterenol Infusions Provide a Reliable Method for Assessing Interoceptive Awareness. Vol. 72, International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2009, pp. 34-45.
  • Khalsa S., Rudrauf D., Damasio A., Davidson R., Lutz A., and Tranel D. Interoceptive Awareness in Experienced Meditators. Vol. 45, Psychophysiology, 2008, pp. 671-7.
  • Khalsa S., Moore S., and Van Hoesen G. Hughlings Jackson and the Role of the Entorhinal Cortex in Temporal Lobe Epilepsy: From Patient A to Doctor Z. Vol. 9, Epilepsy & behavior : E&B, 2006, pp. 524-31.
  • Goldstein R., Leskovjan A., Hoff A., Hitzemann R., Bashan F., Khalsa S., Wang G., Fowler J., and Volkow N. Severity of Neuropsychological Impairment in Cocaine and Alcohol Addiction: Association With Metabolism in the Prefrontal Cortex. Vol. 42, Neuropsychologia, 2004, pp. 1447-58.
  • Stewart J., Khalsa S., Kuplicki R., Puhl M., Investigators T., and Paulus M. Interoceptive Attention in Opioid and Stimulant Use Disorder.
  • Khalsa S., Rudrauf D., Hassanpour M., Davidson R., and Tranel D. The Practice of Meditation Is Not Associated With Improved Interoceptive Awareness of the Heartbeat.
  • DeVille D., Kuplicki R., Stewart J., Paulus M., and Khalsa S. Diminished Responses to Bodily Threat and Blunted Cardiac Interoception in Suicide Attempters.
  • Murphy J., Brewer R., Khalsa S., Catmur C., and Bird G. Testing the Independence of Self-Reported Interoceptive Accuracy and Attention.
  • DeVille D., Whalen D., Breslin F., Morris A., Khalsa S., Paulus M., and Barch D. Predictors of Suicidal Ideation and Behavior in Children in the Adolescent Brain Cognitive Development Study.
  • Ralph-Nearman C., Arevian A., Puhl M., Kumar R., Villaroman D., Suthana N., Feusner J., and Khalsa S. Somatomap: A Novel Mobile Tool to Assess Body Image Perception, Piloted With Fashion Models and Non-Models.
  • Samad M., Ralph-Nearman C., Hellemann G., Khalsa S., Shams L., and Feusner J. Disturbed Eating and Body Dysmorphic Symptoms in a Nonclinical Sample Are Separable Constructs Each With Bimodal Distributions.
  • Stroup R., Khalsa S., Kuplicki R., Puhl M., and Paulus M. Interoceptive Dysfunction in Opioid and Stimulant Use Disorder.
  • Puhl M., Wong C. K., Bodurka J., and Khalsa S. Effect of Cardiorespiratory Perturbations on Cardioballistic Peak Timing in EEG-FMRI.
  • Hassanpour M., Yan L., Wang D., Lapidus R., Arevian A., Simmons W., Feusner J., and Khalsa S. How the Heart Speaks to the Brain: Neural Activity During Cardiorespiratory Interoceptive Stimulation. Philosophical Transactions of the Royal Society B.

Book Chapters

  • Khalsa S., and Feinstein J. “The Somatic Error Hypothesis of Anxiety”. The Interoceptive Mind: From Homeostasis to Awareness, Oxford University Press, 2019.

Manuscripts

  • Khalsa S. Interoception in Eating Disorders: A Clinical Primer. Psychiatric Times, 2019.

Journal Article Reviews

  • Khalsa S., J S., and A B. Treatment-Resistant OCD: Options Beyond First Line Medications. Vol. 10, Current Psychiatry, 2011, pp. 45-52.
  • Paulus M., and Khalsa S. A Computational Approach To Medication Adherence.

Conference Proceedings

  • Lapidus, R. C., Feinstein, J. S., Tulsa 1000 Investigators, Paulus, M. P., & Khalsa, S. S. (March, 2019). Anxiety sensitivity is related to suffocation fear in eating and mood/anxiety disorders. Presented at the 2019 conference of the Anxiety and Depression Association of America, Chicago IL.

  • DeVille, D. C., Kuplicki, R., Tulsa 1000 Investigators, Paulus, M. P., Khalsa, S. S. (May, 2019). Blunted cardiac interoception in suicide attempters. Poster presentation at the 74th Annual Meeting of the Society of Biological Psychiatry. Chicago, IL.

  • DeVille, D. C., Kuplicki, R., Tulsa 1000 Investigators, Paulus, M. P., Khalsa, S. S. (March, 2019). Reduced interoceptive responses to bodily threat in suicide attempters. Poster presentation at the 2019 Anxiety and Depression Association of America (ADAA) Annual Conference. Chicago, IL.

Other

  • Khalsa S., Feinstein J., Simmons W., and Paulus M. Taking Aim at Interoception’s Role in Mental Health. Vol. 3, Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018, pp. 496-8.

Professional Affiliations

  • Genetics and Neuroscience Special Interest Group Chair, Anxiety and Depression Association of America
  • Early Career Special Interest Group Chair, Anxiety and Depression Association of America
  • Society of Biological Psychiatry, Full member
  • Conference Chair, Interoception Summit 2016
  • Society for Neuroscience
  • American Psychiatric Association
  • Gold Humanism in Medicine Honor Society
  • Southern California Psychiatric Association
  • Psychiatric Research Society
  • Academy for Eating Disorders
  • Anxiety and Depression Association of America
  • Oklahoma Psychiatric Physicians Association

Awards & Honors

  • National Institute of General Medical Sciences CoBRE Project Award
  • Thomas Jefferson Scholar
  • Young Neuroscientist Travel Award
  • Medical Student Travel Award
  • Honors Program
  • Scholar/Fellow Travel Award
  • Gold Humanism in Medicine Honor Society
  • Administrative Supplement Award for MD/PhD Psychiatry Trainees
  • Chief Resident
  • Early Career Leadership Award
  • Travel Award
  • Weil Scholar
  • Stuart G. Wolf Scholar Award
  • Patient Oriented Career Development Award (K23)