Syed Hussaini - Faculty & Adjuncts

Syed Hussaini, PhD

Syed Hussaini, PhD
Associate Professor of Chemistry and Biochemistry
College of Engineering & Natural Sciences
Chemistry and Biochemistry
918-631-3520 Website Keplinger Hall Room 2125


PhD – Oxford University MS – University of Karachi BS – University of Karachi


Syed Raziullah Hussaini was born in Karachi, Pakistan. He goes by his middle name, Razi. He received his B.Sc. with honors in 1995 and M.Sc. in Organic Chemistry from the University of Karachi, Pakistan in 1996. After a short stint at Eli Lilly-Gohar(Pvt.) Ltd., he joined the HEJ Research Institute of Chemistry, Pakistan 1997. In 2000, he recived the Lady Noon/OUP scholarship which allowed him to carry out his DPhil at the University of Oxford. The Department of Chemistry and St. Peter's College at Oxford provided him with the bursaries to meet the university and the college fees respectively. In Oxford, Razi joined Dr. Mark Moloney's group in 2001 and finished his DPhil studies in 2004. Afterward, he moved across the Atlantic to work with Dr. Robert B. Grossman at the University of Kentucky. In 2005, he moved to Emory University and worked as a postdoc with Dr. Simon Blakey. In 2006, he moved back to the University of Kentucky and carried out his postdoctoral work with Dr. Peter Crooks. There, he also started teaching in the Department of Chemistry as a part-time instructor. From 2007-2009, Dr. Hussaini worked at the University of Louisville teaching various undergraduate and graduate level chemistry courses. During this period, he also conducted research with Dr. G. B. Hammond. In 2009, he accepted his current position at The University of Tulsa. He is interested in the synthesis of bioactive compounds.  Currently, the following projects are under investigation: 1. Development of new methods for the synthesis of enaminones. 2. Enantioselective synthesis of anti-smoking agents.

Research Interests

Development of Selective C-C Bond Forming Methods
Domino Reactions
Synthesis of Bioactive Compounds

Teaching Interests

Organic Chemistry
Physical Organic Chemistry
Synthetic Organic Chemistry


Journal Articles

  • Pal, Arpal et al. “Copper-Catalyzed Chemoselective Cross-Coupling Reaction of Thioamides and α-Diazocarbonyl Compounds: Synthesis of Enaminones.” Tetrahedron Letters 58.6 (2017): 586–589. Print.

  • Pal, Arpan et al. “Corrigendum to ‘Copper-Catalyzed Chemoselective Cross-Coupling Reaction of Thioamides and α-Diazocarbonyl Compounds: Synthesis of Enaminones’ [Tetrahedron Lett. 58 (2017) 586–589].” Tetrahedron Letters 58.9 (2017): 902 -. Print.

  • Hussaini, Syed, Raghu Chamala, and Zhiguo Wang. “The Eschenmoser Sulfide Contraction Method and Its Application in the Synthesis of Natural Products .” Tetrahedron 71.36 (2015): 6017–6086. Print.

  • Hussaini, Syed. “Converting Chair-like Transition States into Zig-Zag Projections.” Resonance 19.9 (2014): 846–850. Print.

  • Elliott, M et al. “Identification of Novel Proteasome Inhibitors from an Enaminone Library.” Chemical biology & drug design (2014): n. pag. Print.

  • Koduri N., Wang Z., Cannell G., Cooley K., Lemma T., Miao K., Nguyen M., Frohock B., Castaneda M., Scott H., Albinescu D., and Hussaini S. Enaminones via Ruthenium-Catalyzed Coupling of Thioamides and α-Diazocarbonyl Compounds. Vol. 79, The Journal of organic chemistry, 2014, pp. 7405-14.
  • Koduri N., Hileman B., Cox J., Scott H., Hoang P., Robbins A., Bowers K., Tsebaot L., Miao K., Castaneda M., Coffin M., Wei G., Claridge T., Roberts K., and Hussaini S. Acceleration of the Eschenmoser Coupling Reaction by Sonication: Efficient Synthesis of Enaminones. Vol. 3, RSC Adv., 2013, pp. 181-8.
  • Koduri N., Scott H., Hileman B., Cox J., Coffin M., Glicksberg L., and Hussaini S. Ruthenium Catalyzed Synthesis of Enaminones. Vol. 14, Organic letters, 2012, pp. 440-3.
  • Kimura Y., Nuth, III J., Johnson N., Farmer K., Roberts K., and Hussaini S. Synthesis of Stacked-Cup Carbon Nanotubes in a Metal Free Low Temperature System. Vol. 3, Nanoscience and Nanotechnology Letters, 2011, pp. 4-10.
  • Hussaini S., and Hammond G. Eschenmoser Coupling Reaction of Selenoamides. Synthesis of Enamino Ester. Vol. 2008, Arkivoc, 2008, pp. 129-36.
  • Hussaini S., and Moloney M. 2,5-Disubstituted Pyrrolidines: Synthesis by Enamine Reduction and Subsequent Regioselective and Diastereoselective Alkylations. Vol. 4, Organic & biomolecular chemistry, 2006, pp. 2600-15.
  • Faulkner J., Hussaini S., Blankenship J., Pal S., Branan B., Grossman R., and Schardl C. On the Sequence of Bond Formation in Loline Alkaloid Biosynthesis. Vol. 7, Chembiochem : a European journal of chemical biology, 2006, pp. 1078-88.
  • Hussaini S., and Moloney M. Regioselective Reduction of β-Enaminoesters. Vol. 35, Synthetic Communications, 2005, pp. 1129-34.
  • Hussaini S., and Moloney M. Cis-Selective Synthesis of 2,5-Disubstituted Pyrrolidines. Vol. 45, Tetrahedron Letters, 2004, pp. 1125 -27.
  • Hussaini S., and Moloney M. 2,5-Disubstituted Pyrrolidines: Versatile Regioselective and Diastereoselective Synthesis by Enamine Reduction and Subsequent Alkylation. Vol. 1, Organic & biomolecular chemistry, 2003, pp. 1838-41.

Conference Proceedings

  • “Macromonomer Synthesis towards Improving the Healing Efficiency of a Self-Healing Epoxy Matrix”. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 251, 2016.
  • “Synthesis of Norbornene Derivatives for the Incorpoartion into the Matrix of Self-Healing Epoxies”. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 245, 2013.

Courses Taught

  • Research and Thesis
  • Sophomore Seminar
  • Organic Chemistry II
  • Organic Chemistry II Laboratory
  • Research and Dissertation
  • Organic Chemistry I Laboratory
  • Organic Chemistry I
  • Undergraduate Research
  • Physical Organic Chemistry